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Highest Quality | For Research Use Only

Buy ACE-031 Australia Peptide

Ace-031 peptide, also known as ACVR2B or activin receptor type-2B, is a myostatin inhibitor that has been studied for its potential therapeutic applications in the treatment of muscle wasting diseases. Myostatin is a protein that regulates muscle cell growth and differentiation, and inhibiting its function can result in increased muscle mass and strength.

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Potential Benefits of Ace-031 Peptide

  • According to research, ACE-031 peptide exhibits potential in targeting myostatin/activin A signaling, which could be beneficial for treating diseases associated with muscle loss and metabolic dysfunction. This is primarily due to its ability to bind multiple members of the TGF-β family, thereby demonstrating its effectiveness as a receptor antagonist [1].
  • Clinical trials have shown that ACE-031 increases muscle mass and may be effective in treating conditions like cachexia and sarcopenia. The doses used in these studies ranged from 0.02 to 3 mg/kg, and subjects were randomized across six groups [2].
  • Studies suggest ACE-031 peptide has shown promise as a treatment for muscular dystrophy [3]. It was awarded orphan status and accelerated review by the FDA for this indication in 2010 [4].
  • Research indicates that ACE-031 is not just a selective inhibitor but also blocks BMP8, BMP9, and activins [5], expanding its potential application scope in muscle-related disorders.
  • ACE031, a modified version of ACVR2B, has been extensively studied for its potential therapeutic advantages in addressing sarcopenia, a condition characterized by loss of muscle mass and strength associated with aging.[6]. However, its development was halted due to safety concerns.
  • Postmenopausal women administered with ACE-031 showed an increase in lean body mass [7]. This research suggests potential use in countering muscle wasting conditions in postmenopausal women.
  • ACE-031 peptide significantly increased both type 1 and type 2 muscle fibers, according to a study [8]. This makes it a potential agent in enhancing overall muscle strength and function.
  • ACE-2494, an improved version of ACE-031, has been developed and has shown efficacy in stimulating muscle mass and bone growth [9]. This suggests the ongoing evolution and improvement of ACE-031 based treatments.

References

  1. https://academic.oup.com/biomedgerontology/ article/78/Supplement_1/32/7026116
  2. https://www.tandfonline.com/doi/abs/ 10.1517/13543781003724690
  3. https://onlinelibrary.wiley.com/doi/ full/10.17987/jcsm-cr.v2i1.37
  4. https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3819341/
  5. https://journals.lww.com/co-neurology/fulltext/ 2020/10000/the_elusive_promise_of_ myostatin_inhibition_for.12.aspx
  6. https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC7370765/
  7. https://www.sciencedirect.com/science/ article/abs/pii/S8756328217303459
  8. https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC7571243/
  9. https://onlinelibrary.wiley.com/doi/full/ 10.1002/agm2.12168

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