LL-37, also known as cathelicidin antimicrobial peptide, is a critical component of the innate immune response. This 37-amino acid peptide has been extensively studied for its broad-spectrum antimicrobial activity and its modulatory effects on the host immune system.
LL-37 exerts its antimicrobial action primarily through disruption of microbial membranes, leading to cell death. However, it’s not solely an antimicrobial agent; Australia research suggests it also plays a pivotal role in immunomodulation. It can bind to specific receptors, such as the formyl peptide receptor-like 1 (FPRL1) and the purinergic receptor P2X7, triggering a cascade of cellular responses that include chemotaxis, wound healing, and angiogenesis.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC8227053/
[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5374219/
[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3699762/
[4] https://www.sciencedirect.com/science/ article/pii/S2405844019363121
[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3293245/
[6] https://www.sciencedirect.com/science/ article/abs/pii/S1385894722005903
[7] https://pubmed.ncbi.nlm.nih.gov/18456648/
[8] https://pubmed.ncbi.nlm.nih.gov/19542465/
[9] https://pubmed.ncbi.nlm.nih.gov/25101632/
[10] https://pubmed.ncbi.nlm.nih.gov/35634307/
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